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LAT1‐specific inhibitor is effective against T cell‐mediated allergic skin inflammation.
- Source :
-
Allergy . Feb2020, Vol. 75 Issue 2, p463-467. 5p. 1 Color Photograph, 1 Graph. - Publication Year :
- 2020
-
Abstract
- LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation LAT1 inhibition alleviates T cell-dependent dermatitis by suppressing glycolysis/OXPHOS-cyclin/CDK axis in Th2 cells. LAT1 substrate depletion also impaired OXPHOS and glycolysis (Figure S3), implying that the JPH203-mediated down-regulation of OXPHOS and glycolysis is caused by amino acid starvation. The LAT1-glycolysis/OXPHOS-cyclin/CDK axis could provide an advantage to T cells for the adaptive tuning of cytokine production and cell proliferation in response to nutrient shortages (either glucose or amino acids). [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 75
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 141779393
- Full Text :
- https://doi.org/10.1111/all.14019