Forced oscillation technique as method to document and monitor the efficacy of mepolizumab in treating severe eosinophilic asthma.

Mepolizumab is an anti-interleukin-5 monoclonal antibody, approved as add-on treatment for severe eosinophilic asthma, effective in reducing exacerbations and oral corticosteroid use. Moreover, we observed that eosinophil depletion induced by treatment is associated with changes in dynamic airway closure/compression in peripheral lung airways, and treatment-induced changes in peripheral airways function could be effectively monitored by FOT. Forced oscillation technique could become a valuable method to monitor the efficacy of mepolizumab treatment in severe eosinophilic asthma, which changes showed to correlate with both eosinophil counts and asthma control scores. [Extracted from the article]