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放射性同位素碳-14 标记氯虫苯甲酰胺的合成与分析.
- Source :
-
Chinese Journal of Pesticide Science / Nongyaoxue Xuebao . Jan2020, Vol. 22 Issue 1, p19-26. 8p. - Publication Year :
- 2020
-
Abstract
- Two versions of radioisotope carbon-14 labelled chlorantraniliprole, 3-bromo-N-(4-chloro-2- methyl-6-(methyl[carbonyl-14C]carbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5- carboxamide (2, 55.6 mCi, radiochemical purity 99.8%, chemical purity 99.1%, specific activity 52.45 mCi/mmol) and 3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)- 1H-pyrazole-5-[carbonyl-14C]carboxamide (3, 58.6 mCi, radiochemical purity 99.6%, chemical purity 98.4%, specific activity 52.30 mCi/mmol), were synthesized from barium [14C]carbonate via eight-step radioactive reactions including Grignard reaction, nucleophilic substitution, amination reaction, condensation, and etc. Pure C-14 labelled products were obtained after RP-HPLC purification in the overall radiochemical yield of 32% and 52%, respectively. The products were characterized by ESI-MS, 1H NMR and HPLC-FSA. Their technical data was determined by TLC-IIA, HPLC-LSC, HPLCFSA/ PDA/MS and LSC, respectively. These products could be used as radiotracers and meet therequirement of the study on the metabolism of chlorantraniliprole for registration in China. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Chinese
- ISSN :
- 10087303
- Volume :
- 22
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Pesticide Science / Nongyaoxue Xuebao
- Publication Type :
- Academic Journal
- Accession number :
- 141749273
- Full Text :
- https://doi.org/10.16801/j.issn.1008-7303.2020.0003