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(±)-Preisomide: A new alkaloid featuring a rare naturally occurring tetrahydro-2H-1,2-oxazin skeleton from an endophytic fungus Preussia isomera by using OSMAC strategy.
- Source :
-
Fitoterapia . Mar2020, Vol. 141, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- A new alkaloid, named (±)-preisomide (1), together with five known polyketides (2 – 6), were isolated from an endophytic fungus Preussia isomera in Panax notoginseng by using one strain-many compounds (OSMAC) strategy. Their structures were identified by extensive spectroscopic experiments and comparison with literature data. Structurally, compound 1 possessed a rare naturally occurring tetrahydro-2 H -1,2-oxazin ring. Compound 6 displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium , methicinllin-resistant Staphylococcus aureus and multidrug-resistant Enterococcus faecalis with an MIC value of 25 μg/mL, as well as moderate antifungal activity against Gibberella saubinetii with an MIC value of 50 μg/mL. Unlabelled Image [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORGANIC compound analysis
*ALKALOIDS
*ANTI-infective agents
*ANTIFUNGAL agents
*CELL culture
*CHROMATOGRAPHIC analysis
*CULTURE media (Biology)
*FERMENTATION
*FUNGI
*HETEROCYCLIC compounds
*MOLECULAR structure
*SPECTRUM analysis
*ENTEROCOCCUS faecium
*METHICILLIN-resistant staphylococcus aureus
*DESCRIPTIVE statistics
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 141
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 141733837
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104475