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Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial.
- Source :
-
Movement Disorders . Feb2020, Vol. 35 Issue 2, p344-349. 6p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Melatonin may reduce REM-sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking.<bold>Objective: </bold>To assess the efficacy of prolonged-release (PR) melatonin for RBD in PD.<bold>Methods: </bold>Randomized, double-blind, placebo-controlled, parallel-group trial with an 8-week intervention and 4-week observation pre- and postintervention (ACTRN12613000648729). Thirty PD patients with rapid eye movement sleep behavior disorder were randomized to 4 mg of prolonged-release melatonin (Circadin) or matched placebo, ingested orally once-daily before bedtime. Primary outcome was the aggregate of rapid eye movement sleep behavior disorder incidents averaged over weeks 5 to 8 of treatment captured by a weekly diary. Data were included in a mixed-model analysis of variance (n = 15 per group).<bold>Results: </bold>No differences between groups at the primary endpoint (3.4 events/week melatonin vs. 3.6 placebo; difference, 0.2; 95% confidence interval = -3.2 to 3.6; P = 0.92). Adverse events included mild headaches, fatigue, and morning sleepiness (n = 4 melatonin; n = 5 placebo).<bold>Conclusion: </bold>Prolonged-release melatonin 4 mg did not reduce rapid eye movement sleep behavior disorder in PD. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SLEEP disorder diagnosis
*DRUG therapy for Parkinson's disease
*RESEARCH
*EYE movements
*RESEARCH methodology
*POLYSOMNOGRAPHY
*EVALUATION research
*MEDICAL cooperation
*SLEEP disorders
*MELATONIN
*COMPARATIVE studies
*RANDOMIZED controlled trials
*BLIND experiment
*FATIGUE (Physiology)
*CLONAZEPAM
Subjects
Details
- Language :
- English
- ISSN :
- 08853185
- Volume :
- 35
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Movement Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 141721537
- Full Text :
- https://doi.org/10.1002/mds.27886