Experimental Study of Pratia Extact on Acute Liver Injury in Mice.

[Objectives] This Study was conducted lO observe ihe protective effect of Pratia extract on acute liver injury in mice. Methods] Mice were randomly divided into 6 groups according to lxxly weight, 10 in each group: normal control group, elhanol-induced/CCl., liver injury model, low-dose, middle-dose and high-dose Pratia extract groups, and hifendatatum group. Except the blank group, other groups were given 50% eihauol intragaslrically at a dose of 12 ml/kg to cause acute alcoholic liver injury, or inlraperitoneally injected with 10% CC14 soybean oil solution to cause acute CC14 liver injury. The serum ALT and AST activity were measured as well as liver SOD and MUA concentrations. [Results] Pratia exlracl effectively reduced serum ALT and AST, decreased MDA content and increased liver tissue SOD activity. [Conclusions] Pratia extract has certain protective effect on acute liver injury. [ABSTRACT FROM AUTHOR]