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DNA and RNA binding studies on a novel bromo-bridged dimeric copper(II) complex stabilized from a Schiff base ligand.
- Source :
-
Journal of Coordination Chemistry . Nov/Dec2019, Vol. 72 Issue 22-24, p3625-3644. 20p. 5 Diagrams, 6 Charts, 6 Graphs. - Publication Year :
- 2019
-
Abstract
- A novel red copper(II) compound, bis(μ-bromo)bis(2-(benzothiazol-2-yl-hydrazono)-1,2-diphenyl-ethanone)-dicopper(II) (1), has been fostered by equimolar reaction of a Schiff-base ligand, 2-(benzothiazol-2-yl-hydrazono)-1,2-diphenyl-ethanone (LH), with copper(II) bromide in satisfactory yield. 1 has thoroughly been characterized by C, H and N elemental analyses, FT-IR and UV-vis (both in solid state and in solution) spectroscopies, and room-temperature magnetic susceptibility and conductivity measurements. Dimeric 1 bears symmetric rare bromo-bridges in its crystal structure. 1 retains its solid-state identity even in a protic solvent like methanol. 1 in methanol displays two-step one-electron redox response. Theoretical calculations based on DFT were executed to probe the electronic structure of 1 and to augment its color. DNA- and RNA-binding aspects of both LH and 1 have been explored. Thermodynamic binding parameters have been determined. LH is a major-groove binder to DNA, while 1 manifests itself as a minor-groove binder. This binding has been corroborated through molecular docking. Nucleic acid binding aspect of such type of rare bromo-bridged red copper(II) dimer is unprecedented. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SCHIFF bases
*COPPER
*PROTOGENIC solvents
*DNA
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 00958972
- Volume :
- 72
- Issue :
- 22-24
- Database :
- Academic Search Index
- Journal :
- Journal of Coordination Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 141675808
- Full Text :
- https://doi.org/10.1080/00958972.2019.1704276