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Autophagy in cardiomyopathies.
- Source :
-
BBA - Molecular Cell Research . Mar2020, Vol. 1867 Issue 3, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function. In this review, we describe the different forms of mammalian autophagy, their regulations and monitoring with a specific emphasis on the heart. Furthermore, we address the role of autophagy in several forms of cardiomyopathy and the options for therapy. • Autophagy is a highly conserved process that degrades proteins and organelles within lysosomes. • Autophagy plays a major in the regulation of cardiac homeostasis and function. • Different forms, regulation and monitoring of cardiac autophagy are described. • Role of autophagy in several forms of cardiomyopathy and the options for therapy is discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOMYOPATHIES
*AUTOPHAGY
*LYSOSOMES
*HOMEOSTASIS
*CELL anatomy
Subjects
Details
- Language :
- English
- ISSN :
- 01674889
- Volume :
- 1867
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- BBA - Molecular Cell Research
- Publication Type :
- Academic Journal
- Accession number :
- 141663710
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2019.01.013