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'Click' synthesis of cobalt bis(dicarbollide)–cholesterol conjugates.

Authors :
Druzina, Anna A.
Shmalko, Akim V.
Andreichuk, Ekaterina P.
Zhidkova, Olga B.
Kosenko, Irina D.
Semioshkin, Andrey
Sivaev, Igor B.
Mandal, Swadhin
Shen, Zheyu
Bregadze, Vladimir I.
Source :
Mendeleev Communications. Nov2019, Vol. 29 Issue 6, p628-630. 3p.
Publication Year :
2019

Abstract

New conjugates of cholesterol and cobalt bis(dicarbollide) were synthesized using 'click' cycloaddition of 3b-(2-azidoethyl) cholest-5-ene and acetylene-equipped cobalt bis(dicarbollides). The synthesized boronated cholesterols can be of interest for liposomal drug delivery for boron neutron capture therapy of cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09599436
Volume :
29
Issue :
6
Database :
Academic Search Index
Journal :
Mendeleev Communications
Publication Type :
Academic Journal
Accession number :
141636348
Full Text :
https://doi.org/10.1016/j.mencom.2019.11.007