190 Predictors of Response to Low Dose Estradiol Vaginal Inserts for Moderate to Severe Dyspareunia.

Basic science research has shown that vaginal epithelial estradiol receptors have a reciprocal relationship with estradiol blood test values: the higher the density of receptors, the lower the values. Hypothetically, a low dose (4 g, 10 g) of intravaginal estradiol, while not increasing estradiol blood values, should act on the highest density of vaginal epithelial estradiol receptors. Being a responder at week 2 highly predicted being a responder at week 12 in the total EE population (OR 13.1; 95% CI, 8.8-19.7) and in the estradiol vaginal insert groups (OR 7.9; 95% CI, 4.7-13.2). [Extracted from the article]