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State of the art – sirtuin 1 in kidney pathology – clinical relevance.
- Source :
-
Advances in Medical Sciences (Elsevier Inc.) . Sep2019, Vol. 64 Issue 2, p356-364. 9p. - Publication Year :
- 2019
-
Abstract
- Sirtuins represent a group of nicotinamide adenine dinucleotide dependent histone deacetylases, which regulates various biological pathways by promoting chromatin silencing and transcriptional repression. Therefore, they are linked to cellular energy metabolism, mitochondrial biogenesis, stress response, apoptosis, inflammation and fibrosis. Since sirtuin 1 became a promising candidate for targeted therapies of numerous conditions, researchers have been investigating its activator. As for now, natural agents and antidiabetic drug – metformin, have been found to activate sirtuin 1. Sirtuin 1 is able to improve kidney outcomes by direct impact on kidney cells, regulation of non-specific processes generally involved in pathogenesis of age–dependent and metabolic disorders and improvement of the comorbid diseases. This review discusses the state of the art knowledge on the role of sirtuin 1 on kidney pathology. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KIDNEYS
*COMORBIDITY
*PATHOLOGY
*ENERGY metabolism
*SIRTUINS
*MOLECULAR pathology
Subjects
Details
- Language :
- English
- ISSN :
- 18961126
- Volume :
- 64
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Advances in Medical Sciences (Elsevier Inc.)
- Publication Type :
- Academic Journal
- Accession number :
- 141581902
- Full Text :
- https://doi.org/10.1016/j.advms.2019.04.005