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Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine.
- Source :
-
Russian Chemical Bulletin . Dec2019, Vol. 68 Issue 12, p2205-2215. 11p. - Publication Year :
- 2019
-
Abstract
- New allocolchicine derivatives bearing 2,3-dihydrobenzo[b]oxepine moiety were synthesized via gold-catalyzed cyclization as a key synthetic step. The obtained 2,3-dihydrobenzo[b]oxepine-containing allocolchicinoids possess cytotoxic activity against HEK293, PANC-1, COL0357, HeLa, and Colon26 cancer cell lines at low micromolar range of concentrations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL lines
*CANCER cells
*ANTINEOPLASTIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 68
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 141561386
- Full Text :
- https://doi.org/10.1007/s11172-019-2689-7