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Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy.
- Source :
-
Molecular Cancer . 1/30/2020, Vol. 19 Issue 1, p1-19. 19p. 7 Diagrams, 2 Charts. - Publication Year :
- 2020
-
Abstract
- Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a variety of tumors, but resistance during treatment is a major issue. In this review, we describe the utility of PD-L1 expression levels, mutation burden, immune cell infiltration, and immune cell function for predicting the efficacy of PD-1/PD-L1 blockade therapy. Furthermore, we explore the mechanisms underlying immunotherapy resistance caused by PD-L1 expression on tumor cells, T cell dysfunction, and T cell exhaustion. Based on these mechanisms, we propose combination therapeutic strategies. We emphasize the importance of patient-specific treatment plans to reduce the economic burden and prolong the life of patients. The predictive indicators, resistance mechanisms, and combination therapies described in this review provide a basis for improved precision medicine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14764598
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Molecular Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 141474274
- Full Text :
- https://doi.org/10.1186/s12943-020-1144-6