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Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.

Authors :
Oldenburg, Catherine E
Hinterwirth, Armin
Sié, Ali
Coulibaly, Boubacar
Ouermi, Lucienne
Dah, Clarisse
Tapsoba, Charlemagne
Cummings, Susie L
Zhong, Lina
Chen, Cindi
Sarkar, Samarpita
Bärnighausen, Till
Lietman, Thomas M
Keenan, Jeremy D
Doan, Thuy
Source :
Clinical Infectious Diseases. 2/1/2020, Vol. 70 Issue 3, p525-527. 3p.
Publication Year :
2020

Abstract

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10584838
Volume :
70
Issue :
3
Database :
Academic Search Index
Journal :
Clinical Infectious Diseases
Publication Type :
Academic Journal
Accession number :
141293420
Full Text :
https://doi.org/10.1093/cid/ciz455