辣椒素酯類物質補充 對運動期間能量代謝與發炎的影響.

Introduction: The literatures review on capsinoids (CSN) has been shown that CSN extracted from CH-19 sweet pepper have increased resting energy expenditure and fat oxidation in animal and human studies. However, little human study was found regarding to oral CSN supplementation can alter energy source reliance on fat oxidation and attenuate inflammatory markers during high-intensity exercise with glycogen depletion protocol. Therefore, the purpose of this study was to determine effects of oral CSN supplementation on markers of energy metabolism and inflammation during exercise period. Methods: Nine subjects (age: 20.4 ± 0.2 years; height: 170.6 ± 3.1 cm; weight: 63.8 ± 3.7 kg; BMI: 21.7 ± 0.7 kg/m2; V ‧O2 max 48.2 ± 2.9 ml/kg/min) with regular activity habit were recruited to perform this cross-over study design, all subjects were randomly assigned into CSN or placebo treatment, separated by a 7 days washout period. Every subject performed a single bout of cycling exercise with glycogen depletion protocol after 30 mg CSN or placebo supplementation accompany by 300 kcal normal diet. Gaseous exchange sample were taken and blood samples were obtained for measures on respiratory exchange rate, glucose, non-esterified fatty acid, glycerol, interlukine-1β, interlukine-6 and tumor necrosis factor α prior to supplementation, before and immediately after exercise. Results: There were no differences in respiratory exchange ratio between CSN and placebo trials. Both glucose responses of CSN or placebo trials were decreased during exercise periods. However, no significant differences were found between CSN and placebo at time points. Lower responses of plasma non-esterified fatty acid and glycerol responses were found in CSN comparing to placebo after 30-min point during exercise period. Additionally, there were no differences in cytokines with interlukine-1β, interlukine-6 and tumor necrosis factor α between CSN and placebo trials. Conclusion: Oral CSN supplementation could stimulate lipid utilization, indicated lower response on plasma non-esterified fatty acids and glycerol during exercise, but did not result to significant change in fat oxidation. Therefore, there is as yet no evidence in the present study to demonstrate the CSN benefit on enhancing whole body fat oxidation and attenuating inflammation during high intensity exercise challenge in young athletes. [ABSTRACT FROM AUTHOR]