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Chemoenzymatic Posttranslational Modification Reactions for the Synthesis of Ψ[CH2NH]‐Containing Peptides.
- Source :
-
Angewandte Chemie International Edition . Jan2020, Vol. 59 Issue 2, p684-688. 5p. - Publication Year :
- 2020
-
Abstract
- The Ψ[CH2NH] reduced amide bond is a peptide isostere widely used in the development of bioactive pseudopeptides. Reported here is a method of chemoenzymatic posttranslational modification for the synthesis of Ψ[CH2NH]‐containing peptides converted from ribosomally expressed peptides. The posttranslational conversion composed of an enzymatic cyclodehydration and facile two‐step chemical reduction achieves deoxygenation of a specific amide bond present in a nonprotected peptide in water. This method generates the Ψ[CH2NH] bond in peptides and is applicable to various peptide sequences, potentially enabling the preparation of a library of Ψ[CH2NH]‐containing peptides. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 141000125
- Full Text :
- https://doi.org/10.1002/anie.201910894