Electroanalysis of isoniazid and rifampicin: Role of nanomaterial electrode modifiers.

Thanks to operational simplicity, speediness, possibility of miniaturization and real-time nature, electrochemical sensing is a supreme alternative for non-electrochemical methodologies in drug quantification. This review, highlights different nanotech-based sensory designs for electroanalysis of isoniazid and rifampicin, the most important medicines for patients with tuberculosis. We first, concisely mention analyses with bare electrodes, associated impediments and inspected possible strategies and then critically review the last two decades works with focus on different nano-scaled electrode modifiers. We organized and described the materials engaged in several categories: Surfactants modifiers, polymeric modifiers, metallic nanomaterials, carbon based nano-modifiers (reduced graphene oxide, multi-walled carbon nanotubes, ordered mesoporous carbon) and a large class of multifarious nano composites-based sensors and biosensors. The main drawbacks and superiorities associated with each array as well as the current trend in the areas is attempted to discuss. Summary of 79 employed electrochemical approaches for analysis of isoniazid and rifampicin has also been presented. • An overview of the clinical significance of precise quantifications of isoniazid and rifampicin is offered. • Necessity of developing sensing approaches instead of non-sensing methodologies for the analysis is deliberated. • Different electrode nano- and nanobio-modifiers for electroanalysis of the drugs are classified and critically reviewed. [ABSTRACT FROM AUTHOR]