HFNC与NPPV治疗急性1型呼吸衰竭的临床效果比较.

Objective: To investigate the clinical efficacy and safety of high-flow nasal cannula (HFNC) and non-invasive positive pressure ventilation (NPPV) in the treatment of type 1 respiratory failure. Methods: 60 patients with acute type 1 respiratory failure admitted to our hospital from September 2016 to December 2017 were randomly divided into the HFNC group and the NPPV group according to the order of admission, 23 patients in each group were treated with HFNC and NPPV treatment respectively. The arterial blood gas pH value, PaCO2, PaO2, oxygenation index, respiratory rate, heart rate were compared before and at 2 h, 24 h and 48 h after treatment. Results: There was no significant difference in the pH value of arterial blood gas before treatment and at 2 h, 24 h and 48 h after treatment (P>0.05). The PaO2 and arterial blood oxygenation index were significantly higher in the two groups at 2 h, 24 h and 48 h after treatment, and gradually increased with time (P<0.05), and at 48 h after treatment, it was significantly higher in the NPPV group than that of the HFNC group (P<0.05). The PaCO2 values at 2 h, 24 h and 48 h after treatment showed no significant difference from those before treatment (P>0.05), while the PaCO2 values in the NPPV group at 48 h after treatment were significantly lower than those in the HFNC group (P<0.05). The respiratory rate at 2 h, 24 h and 48 h after treatment was significantly lower than that before treatment, and gradually decreased with time (P<0.05), and the respiratory rate of NPPV group was significantly higher than those of the HFNC group at 2 h, 24 h and 48 h after treatment (P<0.05). The heart rate at 2 h, 24 h and 48 h after treatment were significantly lower than that before treatment, and gradually decreased with time (P<0.05). [ABSTRACT FROM AUTHOR]