血清肿瘤标志物联合多层螺旋CT和核磁共振对胆管癌的诊断价值及其与组织侵袭分子的关系分析.

Objective: To explore the diagnostic value of combined detection of serum cancer antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), multi-slice spiral CT and nuclear magnetic resonance (MRI) in cholangiocarcinoma, and to analyse the correlation between tumor markers and invasive molecules. Methods: 62 patients with cholangiocarcinoma who were admitted to affiliated Hospital of Chifeng University from January 2017 to August 2018 were selected as cholangiocarcinoma group. Another 55 patients with benign bile duct lesions admitted to our hospital during the same period were selected as the benign bile duct lesion group. The levels of serum CA19-9, CA125 and tissue invasive molecules content were compared between the two groups. The manifestations of multi-slice spiral CT and MRI in patients with cholangiocarcinoma and benign lesions of bile duct were observed. The diagnostic value of serum CA19-9, CA125, multi-slice spiral CT and MRI in cholangiocarcinoma were analyzed. The correlation between serum CA19-9, CA125 levels and tissue invasive molecules content were analyzed. Results: The serum levels of CA19-9 and CA125 in cholangiocarcinoma group were higher than those in benign lesions of common bile duct group. The contents of lysinoyl oxidase-like protein-2 (LOXL2) and transient receptor potential cation channel 7 (TRPM7) in cholangiocarcinoma group were higher than those in benign lesions of common bile duct group. The content of E-cadherin in tissues was lower than that in benign lesions of common bile duct group (P<0.05). Multi-slice spiral CT imaging signs: cholangiocarcinoma can be seen in the common bile duct, hepatic duct round or quasi-round high-density shadow with wall infiltration, irregular nodules in the bile duct, blurred boundaries between the mass and surrounding tissues, cystic duct and neck infiltration of the gallbladder, liver lobe atrophy, lymph node enlargement, etc. Benign bile duct lesions were mostly round or quasi-circular high-density shadow, wall infiltration and lymph node enlargement were rare. MR imaging signs: cholangiocarcinoma intrahepatic bile duct and liver tissue demarcation was not clear, the mass was irregular or lobulated, gallbladder enlargement, intrahepatic and extrahepatic bile duct dilatation in varying degrees, pancreatic duct dilatation, liver lobe atrophy, lymph node enlargement. Benign bile duct lesions were usually "cup-shaped" low-signal filling defect, and "bird's mouth" changed appear above bile duct obstruction. The sensitivity, specificity and accuracy of combined detection of serum CA19-9, CA125, multi-slice spiral CT and MRI in the diagnosis of cholangiocarcinoma were higher than those of CA19-9, CA125, multi-slice spiral CT and MRI alone. The serum levels of CA19-9 and CA125 in patients with cholangiocarcinoma were positively correlated with tissue LOXL2 and TRPM7 content, but negatively correlated with tissue E-cadherin content (P<0.05). Conclusion: The combined detection of serum CA19-9, CA125, multi-slice spiral CT and MRI has a good value in the diagnosis of cholangiocarcinoma. The levels of serum CA19-9 and CA125 in patients are correlated with tissue invasive molecules, which can provide a basis for the evaluation of malignant degree of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]