Microfluidics approach for determination of the miscibility gap of multicomponent liquid-liquid systems.

• A novel microfluidic approach for determination of binodal compositions is proposed. • A laminar, parallel flow is observed in the microchannel. • Position of the phase interface is captured by an inverse microscope. • Determined miscibility gab is in a good agreement with literature data. The principles of microfluidics have been used to develop a novel method to determine compositions on the binodal of a biphasic system. Within this work, a sound theoretical background of the developed method is given, and its experimental applicability is shown. The method is based on a mass balance that correlates the composition of a heterogeneous, multicomponent biphasic system with the position of the phase interface in the microchannel. The proposed method was validated using a system of water, acetone, and toluene. The calculated compositions on the binodal are in a good agreement with published literature. [ABSTRACT FROM AUTHOR]