Quercetina protege contra dano oxidativo causado por paraquat em fígado e rim de ratos.

Paraquat (Pq) intoxications are frequent in the country and its toxic mechanism of action involves the generation of oxidative stress, which can be combated with exogenous antioxidants such as quercetin (Q). Thus, when assessing the role of this flavonoid in damage caused by Pq, in an experimental animal model, in vitro, a reduction in the level of hepatic lipoperoxidation was observed, suggesting a greater sensitivity of this tissue than the renal. Also, when in association, Pq + Q were able to provoke inhibition of the enzyme d-aminolevulinate dehydratase (d-ALA-D), possibly by chelation mechanism, unrelated to the sulfhydryl groups of the enzyme. In silico, Q presented good intestinal absorption, high plasma protein binding, mutagenic, carcinogenic and inhibitory potential on metabolic enzymes. Thus, it is believed that the diet rich in Q or its supplementation can bring health benefits to the population, especially those exposed to herbicides, such as Pq. [ABSTRACT FROM AUTHOR]