氧化应激对骨重建的影响.

The balance between bone formation and bone resorption maintains the homeostasis of bone remodeling. Aging, estrogen deficiency and other factors lead to the imbalance between the oxidation system and antioxidant system in the body, Resultsing in increased production of reactive oxygen species and oxidative stress. Recent studies have found that oxidative stress induced by reactive oxygen species plays an important role in bone formation and absorption during bone remodeling. Excessive reactive oxygen species affects the nuclear gene transcriptions through regulation of the cytokine expressions, enzyme activity and related signaling pathways, leading to the proliferative and functional abnormalities of bone marrow mesenchymal stem cells, osteoblasts, osteocytes and osteoclasts. The imbalanced bone remodeling may lead to metabolic bone diseases including osteoporosis. Therefore, this article summarized the sources of oxidative stress and its effects on bone marrow mesenchymal stem cells, osteoblasts, osteocytes and osteoclasts as well as the anti-oxidative treatment of osteoporosis in recent years, which is of great significance to further understand the physiological and pathological mechanism of oxidative stress in bone remodeling. [ABSTRACT FROM AUTHOR]