骨钙素水平与超重、2型糖尿病、高血压和HDL-C的关联分析.

Objective To investigate the relationship between osteocalcin levels and obesity, hypertension, type 2 diabetes and HDL cholesterol. Methods From January 2015 to December 2017 in our hospital, 82 subjects affected by both hypertension and type 2 diabetes from the Endocrinology Department, 129 cases who were overweight but unaffected by hypertension or type 2 diabetes, and 135 subjects affected by hypertension but not type 2 diabetes from the Physical Examination Center were selected as subjects. The basic data of all subjects were collected, and fasting blood samples were collected to measure the level of the osteocalcin, blood glucose and plasma lipids levels. Multiple linear regression was used to explore factors associated with osteocalcin level. Results The result of univariate linear regression showed that OC was positively correlated with BMI, waist circumference and HbA1 c, but negatively correlated with systolic blood pressure and HDL-C. Multiple linear regression result showed that OC level had independent positive association with BMI and HbA1 c, and independent negative association with systolic blood pressure and HDL-C. Conclusion The result of this study indicate that overweight and type 2 diabetes are independently and negatively correlated with OC levels, and systolic blood pressure and HDL-C are independently and positively correlated with OC levels. [ABSTRACT FROM AUTHOR]