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Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years.
- Source :
-
Acta Paediatrica . Jan2020, Vol. 109 Issue 1, p85-92. 8p. - Publication Year :
- 2020
-
Abstract
- <bold>Aim: </bold>It is not clear whether perinatal acidosis can predict poor outcomes in extremely preterm infants and we investigated associations between intrapartum hypoxia and mortality and neurodevelopmental outcomes.<bold>Methods: </bold>We used nationwide data on 705 infants from the Extremely Preterm Infants in Sweden Study, delivered at 22-26 weeks of gestation during 2004-2007. Comprehensive neurodevelopmental assessments were performed on survivors at 2.5 (n = 456) and 6.5 (n = 441) years of corrected age. Gestational age-related changes in umbilical cord arterial pH were compared with reference values for term newborn infants, and base excess was also calculated. Associations between low blood gas values (<10th percentile) and mortality and neurodevelopmental outcome were estimated.<bold>Results: </bold>Cord blood determination was more common in surviving infants (P < .001), with pH determined in 322/705 (46%) and base excess in 311/705 (44%). Extremely preterm infants had higher pH values than term infants (P < .0001), with no change from 22 to 26 weeks of gestation (P = .61, r2  = .001). Multiple logistic regression showed no association between low blood gas values and risk of death or neurodevelopmental impairment at 6.5 years (P ≥ .17).<bold>Conclusion: </bold>Hypoxia with acidosis at birth was not associated with an increased risk of death or impaired neurodevelopmental in extremely preterm born children at 6.5 years. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PREMATURE infants
*NEWBORN infants
*ACIDOSIS
*CORD blood
*HYPOXEMIA
*HEALTH outcome assessment
*MORTALITY
*NEUROLOGICAL disorders
*RESEARCH
*BLOOD gases analysis
*RESEARCH methodology
*GESTATIONAL age
*EVALUATION research
*MEDICAL cooperation
*COMPARATIVE studies
*RESEARCH funding
*RESPIRATORY acidosis
Subjects
Details
- Language :
- English
- ISSN :
- 08035253
- Volume :
- 109
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Acta Paediatrica
- Publication Type :
- Academic Journal
- Accession number :
- 140392188
- Full Text :
- https://doi.org/10.1111/apa.14925