生命早期环境内分泌干扰物暴露与儿童过敏性疾病关系的研究进展.

Endocrine disruptor chemicals (EDCs) are similar to steroid hormones in molecular structure, and may have steroid-like disrupting effects on the immune system and influence the risk of allergic diseases. For example, bisphenol A (BPA) and triclosan (TCS) are commonly EDCs existing in the environment, and both BPA and TCS are widely added to daily necessities and catering products. Animal experiments found that prenatal BPA exposure may be associated with higher risk of respiratory allergic diseases in offspring. It was also founda few epidemiological studies that TCS exposure was associated with higher risks of eczema, and allergic disorders in respiratory system and digestive tracts in children. EDCs may increase cytokines and immunoglobulins levelsinterrupting the function of helper T cells (Th1/Th2) so as to affect the immune system, which might be associated with allergic reactions. This review mainly focused on the correlation between EDCs (BPA and TCS) and childhood allergic diseases and the underlying mechanisms. [ABSTRACT FROM AUTHOR]