Human immunity to Toxoplasma gondii.

I Toxoplasma gondii i ( I Tg i ) is an apicomplexan parasite able to invade any nucleated cell in warm-blooded animals. Right: Cellular response to Tg-infection: IFN and potentially other cytokines trigger infected cells to mount a cell-intrinsic defence against the PV. We recently showed that the IFN dose-dependent restriction of I Tg i -infection depends on cell type, with epithelial cells displaying a sharp parasiticidal effect, in contrast to macrophages, fibroblasts, and endothelial cells demonstrating a dose-dependent response [[24]]. This cell death phenotype is dependent on IFN -induced guanylate binding proteins (GBPs), of which GBP1 translocates to I Tg i vacuoles and releases I Tg i -derived molecular ligands of cellular receptors [[27]]. [Extracted from the article]