Binding parameters of defined immune complexes to rat basophilic leukaemia (RBL) cells.

The binding parameters of chemically-defined immune complexes composed of rat IgGa- anti-human serum albumin (USA) to rat basophilic leukaemia cells were analysed. It was demonstrated that the uptake of various sized immune complexes is time-, temperature- and pH-dependent. A higher binding rate was observed with more Fc portions available in the immune complex. A comparison of the binding rate for immune complexes with that of heat aggregates shows that immune complexes bind with greater affinity to the cells. [ABSTRACT FROM AUTHOR]