Respiratory virus infection triggers acute psoriasis flares across different clinical subtypes and genetic backgrounds.

Between February 2011 and November 2018, we enrolled 25 patients including 13 women with PV (21) and GPP (4) at baseline, with a median age of 38 years, consulting for 31 flares with RTI symptoms. Overall, 21 of 25 patients had at least one positive multiplex PCR viral test, with I Rhinovirus i and I Coronavirus i as the most frequently detected pathogens, while only two of 25 bacterial swabs were positive (one each for I Staphylococcus aureus i and I Streptococcus dysgalactiae i ). All patients reported history of previous acute psoriasis flares following RTI, including two patients with GPP/DITRA sharing the homozygous c.80T>C; p.Leu27Pro severe mutation.[6] No genetic abnormality was detected in I IL36RN i , I CARD14 i and I AP1S3 i in other patients. [Extracted from the article]