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Angiopoietin-Like 7 Contributes to Angiotensin II-Induced Proliferation, Inflammation and Apoptosis in Vascular Smooth Muscle Cells.
- Source :
-
Pharmacology . 2019, Vol. 104 Issue 5/6, p226-234. 9p. 6 Graphs. - Publication Year :
- 2019
-
Abstract
- Introduction: Angiotensin II (AngII) induces hypertension and pathophysiological vascular thickening and atherosclerosis. This study aims to validate the effects of Angiopoietin-like 7 (ANGPTL7) in AngII-induced hypertension. Methods: ANGPTL7 in blood samples were determined by quantitative real-time polymerase chain reaction. AngII-induced cell growth were detected by CCK-8. Cell cycle arrest and cell apoptosis by downregulation of ANGPTL7 were detected by flow cytometric assay. AngII-induced inflammation was evaluated by Western blotting and ELISA. Results: ANGPTL7 was highly expressed in patients with hypertension. AngII promoted cell viability and the expression level of ANGPTL7 in vascular smooth muscle cells (VSMC). Downregulation of ANGPTL7 inhibited AngII-induced cell proliferation and cell inflammation. Moreover, ANGPTL7 expression decreases also promoted cell apoptosis. Conclusions: Downregulation of ANGPTL7 reversed AngII-induced cell proliferation and cell inflammation and promoted apoptosis in AngII-induced VSMC cells. Therefore, ANGPTL7 can be a potential target in AngII-induced hypertension. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00317012
- Volume :
- 104
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 140084984
- Full Text :
- https://doi.org/10.1159/000501296