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First-degree family history of diabetes and its relationship with serum osteocalcin levels independent of liver fat content in a non-diabetic Chinese cohort.
- Source :
-
BMC Public Health . 12/3/2019, Vol. 19 Issue 1, pN.PAG-N.PAG. 1p. 1 Chart, 2 Graphs. - Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>First-degree relatives of patients with diabetes (FDR) tend to have impaired insulin activity, which lead to the alternation of circulating cytokine levels. Liver is a main target tissue of insulin action; therefore, liver fat content (LFC) has a close relationship with insulin resistance. This study aimed to find the alteration in serum osteocalcin levels in FDR and the relationship of serum osteocalcin levels with FDR and non-alcoholic fatty liver disease (NAFLD).<bold>Methods: </bold>In total, 1206 subjects including 413 men and 793 women from the communities, aged 59.7 (range, 54.8-64.3) years, were enrolled. An electrochemiluminescence immunoassay was performed to measure the levels of serum osteocalcin. LFC was measured using quantitative ultrasonography.<bold>Results: </bold>A significant decrease was found in serum osteocalcin levels in subjects with NAFLD (P < 0.001) as well as in FDR (19.8 ± 5.7 ng/mL versus 20.7 ± 6.8 ng/mL, P = 0.028). Furthermore, among the subjects with NAFLD, those with FDR had lower levels of osteocalcin than those without FDR (P = 0.011). The presence of FDR remained a predictor for decreased serum osteocalcin levels after adjusting for body mass index, blood glucose, blood lipids, and LFC (standardized β = - 0.057, P = 0.028).<bold>Conclusions: </bold>FDR had lower serum osteocalcin levels than non-FDR. The inverse association between FDR and serum osteocalcin levels was independent of metabolic factors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712458
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Public Health
- Publication Type :
- Academic Journal
- Accession number :
- 140063712
- Full Text :
- https://doi.org/10.1186/s12889-019-7932-5