Methyl-α- d -glucopyranoside as Green Ligand for Selective Copper-Catalyzed N-Arylation.

In the selective N-arylation of amines or azoles with aryl halides-, methyl-α- d -glucopyranoside (MG) was found to function as a green ligand of copper powder. In addition, nitrogen heterocyclic amine compounds can also undergo the N-arylation coupling with heterocyclic aryl chlorides. This process allows access to a variety of aromatic amines and aryl azoles under mild reaction conditions, has good tolerance, and proceeds in moderate to high yield. [ABSTRACT FROM AUTHOR]