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A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice.

Authors :
Brickell, P. M.
McConnell, I.
Milstein, C.
Wright, B.
Source :
Immunology. Jul81, Vol. 43 Issue 3, p493-501. 9p.
Publication Year :
1981

Abstract

A rat monoclonal antibody which recognizes a product of the HLA-DR locus is described. The determinant recognized by this antibody is monomorphic in man but polymorphic in mice. Mapping studies with inbred and recombinant strains of mice show that this antigen is associated with H-2 haplotypes b, d and q and is coded for by genes within the I-A subregion. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00192805
Volume :
43
Issue :
3
Database :
Academic Search Index
Journal :
Immunology
Publication Type :
Academic Journal
Accession number :
13999817