Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms from Nalidixic Acid and 2-Aminophenol and Metal Complexes and Evaluation of their Biological Activity.

In this study, a novel Schiff base (E)-1-ethyl-4-(2-hydroxyphenylimino)-7-methyl-1,4-dihydro-1,8 naphthyridine-3- carboxylic acid (H2L) was synthesized from nalidixic acid and 2-Aminophenol and it's complexes with metal ions M=VO, Mn, Co, Ni, Cu,Zn, Pd and Ptinethanolandacetic acid with moleratio(M:L)(1:2).All complexes have general composition ([VO (L)(H2O)], K2 [Mn(L)2]H2O, K2 [Co(L)2] H2O, K2 [Ni(L)2], [Zn(L) (H2O)], [Pd(KL)2] H2O, [Pt(KL)Cl2]) where: L- = C18H16N3O3. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UVVis, 1HNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against one type of bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry accept[Zn(L)(H2O)] tetrahedral geometry and [Pd(KL)2]H2OSquare planer geometry, [VO (L)(H2O)] square pyramidel. The value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligand and starting material. [ABSTRACT FROM AUTHOR]