Effects of feeding bacterial lipopolysaccharide and dextran sulphate on the development of oral tolerance to contact sensitizing agents.

The effect of feeding the B-cell mitogens Escherichia coli lipopolysaccharide and dextran sulphate on the development of orally induced tolerance to the contact sensitizing agent picryl chloride was studied in mice. Feeding either agent throughout the experiment or during tolerization, increased the tolerizing effect of a single feed of picryl chloride. [ABSTRACT FROM AUTHOR]