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Synthesis of Reconfigurable Flow-Based Biochips for Scalable Single-Cell Screening.

Authors :
Ibrahim, Mohamed
Sridhar, Aditya
Chakrabarty, Krishnendu
Schlichtmann, Ulf
Source :
IEEE Transactions on Computer-Aided Design of Integrated Circuits & Systems. Dec2019, Vol. 38 Issue 12, p2255-2270. 16p.
Publication Year :
2019

Abstract

Single-cell screening is used to sort a stream of cells into clusters (or types) based on prespecified biomarkers, thus supporting type-driven biochemical analysis. Reconfigurable flow-based microfluidic biochips (RFBs) can be utilized to screen hundreds of heterogeneous cells within a few minutes, but they are overburdened with the control of a large number of valves. To address this problem, we present a pin-constrained RFB design methodology for single-cell screening. The proposed design is analyzed using computational fluid dynamics simulations, mapped to an RC-lumped model, and combined with intervalve connectivity information to construct a high-level synthesis framework, referred to as cell sorter using multiplexed control (Sortex). Simulation results show that Sortex significantly reduces the number of control pins and fulfills the timing requirements of single-cell screening. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02780070
Volume :
38
Issue :
12
Database :
Academic Search Index
Journal :
IEEE Transactions on Computer-Aided Design of Integrated Circuits & Systems
Publication Type :
Academic Journal
Accession number :
139785895
Full Text :
https://doi.org/10.1109/TCAD.2018.2878159