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Prevention of Obesity-Induced Nonalcoholic Fatty Liver Disease Using Grape Pomace Extract.
- Source :
-
Current Topics in Nutraceutical Research . Nov2019, Vol. 17 Issue 4, p415-421. 7p. - Publication Year :
- 2019
-
Abstract
- The objective of this study was to examine the effect of grape pomace extracts on obesity-induced nonalcoholic fatty liver disease (NAFLD) in rats. To this end, forty male Wistar rats were assigned into four groups and were fed regular chow, high-fat diet, high-fat diet plus low-dose grape pomace extract (0.5%, w/w) or high-dose (2%, w/w) grape pomace extract (GPE) for 16 weeks. We observed that lipid concentrations (triglyceride and cholesterol) were elevated in the plasma and liver in rats on a high-fat diet and also on those receiving 2% GPE with high-fat diet. These changes were resulting from the downregulation of lipogenic enzymes and stimulation of hepatic lipolysis. A high-fat diet-mediated increase in hepatic oxidative stress was reduced by GPE. The plasma levels of proinflammatory cytokines TNF-α and IL-6 were significantly decreased by GPE. These results suggest that the supplementation with GPE may ameliorate adiposity, hepatic steatosis, oxidative stress and inflammation in high-fat diet-fed rats and potentially retard the development of obesity-induced NAFLD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15407535
- Volume :
- 17
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Current Topics in Nutraceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 139619812