417. Cytomegalovirus (CMV) and Sexually Transmitted infections (STIs) During Pregnancy.

Background Congenital cytomegalovirus infection (cCMV) is a leading cause of hearing loss and neurodevelopmental disabilities. Although higher rates of CMV acquisition and reinfections with new virus strains are seen in women with STIs, the significance of CMV-STI co-infections during pregnancy and whether co-infections increase intrauterine transmission of CMV remains unclear. Higher rates of CMV genital shedding were seen in mothers of infants with cCMV compared with those with uninfected infants. The objective of this study was to determine the association between CMV seroprevalence and STIs and whether STIs during pregnancy influences CMV genital shedding. Methods Vaginal swabs from a cohort of CMV seropositive women in labor from a multi-center study were analyzed. After DNA extraction from vaginal swabs, PCR was performed for detection of CMV, Neisseria gonorrhoeae (GC) , Chlamydia trachomatis (CT) , Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG). The prevalence of STIs in CMV seropositive pregnant women was determined in this cohort and CMV genital shedding rates were compared between groups with and without STIs. Results In this cohort, CMV genital shedding in late pregnancy was detectable in 13% (21/160) of women while rates of detection for MG, GC, CT and TV were 3%, 0.6%, 1.2% and 8%, respectively. CMV-STI co-infections were noted in 2.5% (4/160) of women. CMV genital shedding was documented in only one woman with STIs, compared with 12.5% (20/160) without STIs. Among women shedding CMV in the genital tract, CMV viral load levels ranged from 1.1 × 102 IU/mL to 2.2 × 104 IU/mL. Conclusion In a cohort of CMV seropositive women, the presence of STIs in late pregnancy did not increase CMV genital shedding. Our preliminary findings suggest CMV shedding is not associated with STIs detected late in pregnancy. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR]