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Ontogenetic Pleiotropy of Genes Involved in CNVs in Human Spontaneous Abortions.
- Source :
-
Russian Journal of Genetics . Oct2019, Vol. 55 Issue 10, p1214-1226. 13p. - Publication Year :
- 2019
-
Abstract
- Using chromosome microarray analysis, 52 samples of placental tissues from first trimester human spontaneous abortions were examined. One hundred twenty copy number variations (CNVs) were identified, affecting one or more genes (total of 427 genes). Using enrichment analysis with the mammalian phenotype ontology, all genes were divided into 183 categories (p ≤ 0.05). The embryogenesis category included 22 genes: AIP, BMP4, BMP5, CDKN1C, EXT1, GAB1, H19, HOXD13, IGF2, KIT, LDHA, NKX2-5, NRK, PEG3, PHLDA2, SMCHD1, SMN1, TBX3, TGIF1, TH, TLX2, and TRR. In this paper, the functions of each of the above genes and pathological phenotypes associated with mutations in them are discussed. A hypothesis of the pleiotropic effect of genes involved in CNVs in spontaneous abortions is proposed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MISCARRIAGE
*CHROMOSOME analysis
*GENES
Subjects
Details
- Language :
- English
- ISSN :
- 10227954
- Volume :
- 55
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 139315549
- Full Text :
- https://doi.org/10.1134/S1022795419100065