Back to Search
Start Over
Glycolytic Inhibitor 2-Deoxy-D-Glucose at Chronic Low Dose Mimics Calorie Restriction in Rats Through Mitohormetic Induction of Reactive Oxygen Species.
- Source :
-
Rejuvenation Research . Oct2019, Vol. 22 Issue 5, p377-384. 8p. - Publication Year :
- 2019
-
Abstract
- Caloric restriction mimetics (CRMs) provide an exciting antiaging intervention strategy. 2-Deoxy-D-glucose (2-DG), a glycolytic inhibitor, is known to work as a CRM at high doses; however, at chronic high dose it has been linked to increased mortality in rats. We have investigated chronic low-dose dietary administration of 2-DG on age-related stress protection in young and old male Wistar rats by evaluating age-dependent biomarkers in plasma and erythrocytes. Significant increase was observed in reactive oxygen species levels in 2-DG-treated rats (both young and old), concomitant with increase in activities of erythrocyte plasma membrane redox system (PMRS), catalase (CAT), and superoxide dismutase (SOD). 2-DG treatment also decreased plasma sialic acid and advanced glycation end products. We propose that 2-DG induces a mitohormetic response resulting in augmentation of defense mechanism(s) manifested by higher activity of PMRS, CAT, and SOD. Our findings provide evidence that at chronic low dose 2-DG could be a potential CRM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15491684
- Volume :
- 22
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Rejuvenation Research
- Publication Type :
- Academic Journal
- Accession number :
- 139227850
- Full Text :
- https://doi.org/10.1089/rej.2018.2125