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A Case of Gastric Amphicrine Signet-Ring Cell Carcinoma.
- Source :
-
Clinical Pathology . 2019, Vol. 12 Issue 1-4, p1-3. 3p. - Publication Year :
- 2019
-
Abstract
- “Amphicrine” (in Greek, amphi-means “both” or “double”) refers to cells that synchronously exhibit the endocrine and exocrine phenotypes. Gastric amphicrine carcinoma is very rare, and only a few case reports are found in the English literature; thus, its pathobiological features remain unclear. Here, we report a case of amphicrine gastric carcinoma. A woman in her sixth decade of life presented with anemia and underwent upper endoscopy, followed by histopathological examination of biopsy specimens. She appeared to have gastric cancer with a tumor measuring 5.0 cm × 4.0 cm in size. Subsequently, the patient underwent total gastrectomy with lymph node dissection. Histopathological examination revealed a poorly cohesive carcinoma that sparsely coexisted with signet-ring cell carcinoma cells with regional lymph node metastasis. Interestingly, synaptophysin immunoreactivity with the coexistence of Alcian blue was found in individual signet-ring cell carcinoma cells. Furthermore, the present amphicrine carcinoma cells immunohistochemically expressed CD44 variant 9, a functional cancer stem cell marker. We believe that the present case findings may support the idea of multipotent stem cells being an origin of amphicrine gastric cancers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2632010X
- Volume :
- 12
- Issue :
- 1-4
- Database :
- Academic Search Index
- Journal :
- Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 139222377
- Full Text :
- https://doi.org/10.1177/2632010X19880535