Back to Search
Start Over
NQDI-1 protects against acinar cell necrosis in three experimental mouse models of acute pancreatitis.
- Source :
-
Biochemical & Biophysical Research Communications . Nov2019, Vol. 520 Issue 1, p211-217. 7p. - Publication Year :
- 2019
-
Abstract
- NQDI-1, an inhibitor of ASK1, has been reported to have protective effects in several experimental human disease models. However, the role of NQDI-1 in acute pancreatitis (AP) has not been reported. In this study, we found that NQDI-1 could attenuate histological damage of pancreatic tissue as well as the levels of serum amylase and lipase in a mouse model of AP induced by caerulein. Moreover, the production of reactive oxygen species (ROS) and the expression of necrosis-related proteins (RIP3 and p-MLKL) were also reduced after NQDI-1 administration. Correspondingly, we elucidated the effect of NQDI-1 in vitro and found that NQDI-1 protected against pancreatic acinar cells necrosis via decreasing the ROS production and RIP3 and p-MLKL expression. In addition, we identified the protective effect of NQDI-1 on AP through two other mouse models induced by l -arginine and pancreatic duct ligation. Taken together, these findings showed that NQDI-1 could reduce the acinar cells necrosis and alleviate the severity of AP, which may afford a new therapeutic target on pancreatic necrosis in AP clinically. • NQDI-1 alleviates acinar cell necrosis of acute pancreatitis in three experimental mouse models. • NQDI-1 inhibits ROS aggregation and down-regulate the necrosis pathway. • NQDI-1 may be a therapeutic candidate for acute pancreatitis in clinical. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 520
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 139190883
- Full Text :
- https://doi.org/10.1016/j.bbrc.2019.09.125