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Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia.
- Source :
-
Schizophrenia Research . Oct2019, Vol. 212, p79-85. 7p. - Publication Year :
- 2019
-
Abstract
- <bold>Introduction: </bold>To investigate the impact of a polygenic risk score for schizophrenia (PRS-SZ) and urbanicity on the risk of treatment-resistant schizophrenia (TRS) in people diagnosed with schizophrenia and to evaluate the association between PRS-SZ and TRS across levels of urbanicity.<bold>Methods: </bold>Cohort study of people born after 1981 with a first registered diagnosis of schizophrenia between 1996 and 2012 using Danish population registry data. Through linkage to genome-wide data, we calculated PRS-SZ based on a Psychiatric Genomics Consortium meta-analysis. We assessed urbanicity at birth (capital, provincial and rural areas). TRS was defined using prescription and hospital data. Performing Cox regression analysis, we calculated hazard rate ratios (HRs) and 95% confidence intervals (CI).<bold>Results: </bold>Among 4475 people with schizophrenia, we identified 593 (13.3%) with TRS during 17,558 person years of follow-up. The adjusted HR for TRS associated with one standard deviation (SD) increase in the PRS-SZ was 1.11 (95% CI: 1.00-1.24). The adjusted HRs for TRS across levels of urbanicity were 1.20 (95% CI: 0.98-1.47) for provincial areas and 1.19 (95% CI 0.96-1.47) for rural areas compared with the capital area. Within strata of urbanicity, the adjusted HR for TRS was 1.39 (95% CI: 1.14-1.70) in the capital area with 1 SD increase in the PRS-SZ, 0.99 (95% CI 0.84-1.17) in provincial areas, and 1.03 (95% CI: 0.86-1.25) in rural areas.<bold>Conclusion: </bold>The effect of genetic liability (i.e. PRS) on risk of TRS varied across urbanicity levels and was highest for people with schizophrenia born in the capital areas. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SCHIZOPHRENIA
*REGRESSION analysis
*STANDARD deviations
*RURAL geography
*CONFIDENCE intervals
*DIAGNOSIS of schizophrenia
*SCHIZOPHRENIA treatment
*RELATIVE medical risk
*RESEARCH
*GENETICS
*RESEARCH methodology
*EVALUATION research
*MEDICAL cooperation
*TREATMENT failure
*COMPARATIVE studies
*DISEASE susceptibility
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 212
- Database :
- Academic Search Index
- Journal :
- Schizophrenia Research
- Publication Type :
- Academic Journal
- Accession number :
- 139057876
- Full Text :
- https://doi.org/10.1016/j.schres.2019.08.008