Venetoclax and hypomethylating agents in TP53‐mutated acute myeloid leukaemia.

We conducted a retrospective analysis of AML patients treated with the combination of VEN/HMA at our institution between June 2016 and April 2019. Furthermore, we also show a promising CR/CRi rate (38%) in patients with r/r I TP53 i m AML, which includes some patients relapsing after prior alloHCT. Most patients in our cohort received decitabine as their HMA, and this preference may have been influenced by results of a study utilising 10-day courses of decitabine in I TP53 i m myeloid neoplasms and yielding a 100% response rate (Welch I et al i , [10]). Although our preliminary results with VEN/HMA appear favourable compared to the dismal outcomes reported in I TP53 i m AML patients when treated with conventional combination chemotherapy (Grossmann I et al i , [5]; Rucker I et al i , [7]), the median LFS was relatively short, and relapses occurred frequently. [Extracted from the article]