Evolution of platelet function in adult patients with chronic immune thrombocytopenia on romiplostim treatment.

Keywords: platelet function; flow cytometry; immune thrombocytopenia; bleeding risk; romiplostim Immune thrombocytopenia (ITP) is an autoimmune disease caused by auto-antibodies against platelets. Prior to treatment, 9 patients had bleeding complications and 22 patients were asymptomatic. In contrast, platelet activation responses to potent stimulation with thrombin plus collagen receptor agonists were not essentially affected in ITP, and did not differ between the bleeding and non-bleeding groups (Fig I; Figure S1F-I). [Extracted from the article]