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Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction.

Authors :
Kumar, Anupam A.
Kelly, Daniel P.
Chirinos, Julio A.
Source :
Circulation. 3/12/2019, Vol. 139 Issue 11, p1435-1450. 16p.
Publication Year :
2019

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abnormalities can significantly contribute to impaired oxygen utilization and the resulting exercise intolerance in HFpEF. We review key aspects of the complex biology of this organelle, the clinical relevance of mitochondrial function, the methods that are currently available to assess mitochondrial function in humans, and the evidence supporting a role for mitochondrial dysfunction in the pathophysiology of HFpEF. We also discuss the role of mitochondrial function as a therapeutic target, some key considerations for the design of early-phase clinical trials using agents that specifically target mitochondrial function to improve symptoms in patients with HFpEF, and ongoing trials with mitochondrial agents in HFpEF. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00097322
Volume :
139
Issue :
11
Database :
Academic Search Index
Journal :
Circulation
Publication Type :
Academic Journal
Accession number :
139031568
Full Text :
https://doi.org/10.1161/CIRCULATIONAHA.118.036259