内质网应激在肝衰竭发病机制中的作用.

Liver failure is a severe liver disease with a complex pathological process, rapid disease progression, and a high mortality rate, and in-depth studies are needed to explore its pathogenesis. Early and mild endoplasmic reticulum stress( ERS) can maintain the stability of intracellular environment through unfolded protein reaction, while persistent and severe ERS may promote inflammatory response and apoptosis and cause cell death, and therefore, ERS plays a key role in the development and progression of liver failure. This article elaborates on the role of ERS and related signaling pathways in the pathogenesis of liver failure, so as to provides new ideas for the treatment of liver failure. [ABSTRACT FROM AUTHOR]