T21ESTIMATING POLYGENICITY AND EFFECT-SIZE DISTRIBUTION IN FUNCTIONAL CATEGORIES OF THE GENOME USING SUMMARY STATISTICS DATA FROM GENOME-WIDE ASSOCIATION STUDIES.

B Background: b Current studies of genetic architecture are often focused on the estimation of SNP-heritability. We propose a causal mixture model which estimates the number of non-null variants and the distribution of their effect sizes across different functional categories of the genome investigation of trait genetic architecture beyond SNP-heritability. Variant effect sizes are modelled with point-normal mixture prior, where both proportion of non-null variants and distribution of their effect sizes can vary between different functional categories of the genome. [Extracted from the article]