54 GENOME-WIDE ASSOCATIONS WITH DEPRESSIVE SYMPTOMS IN THE MILLION VETERANS PROGRAM.

B Methods: b We conducted a genome-wide association study (GWAS) on 175,553 participants in the MVP who completed a survey that included the PHQ2 (two questions about mood state within the past two weeks), had genomic data and were of genetically assigned European descent. The polygenic risk score software PRSice2 was used to identify individual common SNP genetic liability from polygenic risk scores for depression in the MVP sample and available PGC and UKB summary statistics. We observed positive genetic correlations between depression and neuroticism, insomnia, and smoking initiation and negative genetic correlation between depression and subjective well-being and intelligence. [Extracted from the article]