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Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
- Source :
-
Chemical Communications . 10/7/2019, Vol. 55 Issue 78, p11671-11674. 4p. - Publication Year :
- 2019
-
Abstract
- We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DNA ligases
*OLIGONUCLEOTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 78
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 138830091
- Full Text :
- https://doi.org/10.1039/c9cc05476f