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Galectin-3 may serve as a marker for poor prognosis in colorectal cancer: A meta-analysis.
- Source :
-
Pathology - Research & Practice . Oct2019, Vol. 215 Issue 10, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
-
Abstract
- Galectin-3 has an important function in the development of tumors. The purpose of this meta-analysis was to explore the relationships between the expression of galectin-3 on clinicopathological features and prognosis of colorectal cancer (CRC). A comprehensive literature search was used to identify eligible studies, and Stata software was conducted using in this meta-analysis. A total of 15 studies, including 1661 cases, were matched in the inclusion criteria. The pooled analysis indicated that galectin-3 expression was related to the poor overall survival (OS) in CRC patients (HR: 1.77, 95% CI: 1.36–2.31, P < 0.0001). Our meta-analysis also showed that cancerous tissues have higher levels of galectin-3 expression than normal tissues. Besides, positive galectin-3 expression was also related to advanced TNM stages(III/IV vs. I/II: OR 5.30, 95% CI: 2.42–11.61, P < 0.0001), higher Duke's stages (C/D vs. A/B: OR 4.00, 95% CI: 2.22–7.22, P < 0.0001), venous invasion (venous invasion vs. not: OR 3.02, 95%CI: 1.75–5.22, P < 0.0001) and higher CEA level (CEA≥5 ng/ml vs. ≤ 5 ng/ml: OR 2.09, 95% CI: 1.09–4.03, P = 0.03). In summary, our results indicated that overexpression of galectin-3 is significantly related to the tumor progression and could be a efficient in predicting the prognosis of patients with CRC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER prognosis
*COLORECTAL cancer
*META-analysis
*CANCER invasiveness
Subjects
Details
- Language :
- English
- ISSN :
- 03440338
- Volume :
- 215
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Pathology - Research & Practice
- Publication Type :
- Academic Journal
- Accession number :
- 138728038
- Full Text :
- https://doi.org/10.1016/j.prp.2019.152612